The article entitled “Physical activity-dependent regulation of parathyroid hormone and calcium-phosphorous metabolism” looks upon how exercise may contribute to alterations of parathyroid function through changing the levels of mediators and hormones. Lombardi et al. (2020) investigate how physical training impacts calcium and phosphate levels through energy consumption and look into the effects of parathyroid hormone on regulating calcium and phosphate homeostasis. Since PTH metabolism leads to hyperparathyroidism and hypoparathyroidism, it is important to study if the onset of these diseases may be delayed and the quality of life of these patients improved through regular physical exercise.
The article states that hypoparathyroidism is provoked by a permanent or non-permanent lack of PTH. The disease can “cause seizures, severe arrhythmias, laryngospasm, dyspnea, and bronchospasm” (Lombardi et al., 2020, p.8). Lombardi et al. (2020) carried out measurements to see whether physical exercise leads to PHP production changes. It was found out that while exercise affects PTH response not directly but through calcium homeostasis, it can still modify PTH levels, significantly increasing them (Lombardi et al., 2020). Moreover, the more intensive and regular the exercises are, the more PHT is produced.
Physical exercise, leading to the increase in PHP production, is beneficial for this group of patients since increasing the level of PHP reduces bronchospasm and arrhythmias. While exercise affects PTH response not directly but through calcium homeostasis, it has been found that it is still able to modify PTH levels (Lombardi et al., 2020). Moreover, the more intensive and regular the exercises are, the more PHT is produced.
The article is especially relevant since it determines the correlation between PTH levels and physical activity. Patients suffering from hypoparathyroidism may be advised to do sports to improve their health. The article connects to pathophysiology as it suggests an alternative way of treating hypoparathyroidism. Though physical exercise can not substitute for proper treatment, it can significantly improve the patients’ well-being and level of life.
Lombardi, G., Ziemann, E., Banfi, G., & Corbetta, S. (2020). Physical activity-dependent regulation of parathyroid hormone and calcium-phosphorous metabolism. International Journal of Molecular Sciences, 21(15), 5388.Barner, C. (2012). Social media and communication. Sage.