The main objective of using hospital formularies in clinical conditions is providing complete satisfaction with the medication needs of a certain group of patients. In this study, we provide the criteria for selecting a specific drug group, which is represented in a hospital formulary. In fact, one can state that choosing the type of medicine relies on three critical factors, which include disease characteristics, use safety, and general cost-effectiveness. Therefore, in this work, the selection of optimal antimicrobial medicine, which is based on the mentioned criteria, is offered. The material for the analysis is provided by the employment of the Ethiopian National Drug Formulary, which was developed by the State Drug Administration.
Every hospital formulary prioritizes a certain class of anti-infectives, which are employed either with the aim of killing infectious agents or inhibiting them from spreading. In this work, we select three major types of antimicrobial medicaments, which comply with the optimal anti-infective use that may be employed in diverse patient groups. Specifically, amoxicillin, ampicillin, and carbenicillin are prioritized. The choice of the medication was stipulated by use safety, storage optimization, and availability.
Thus, three medicaments, in opposition to penicillin, which is widely used as an anti-infectious drug, do not pose consistent danger cautions that may lead to fatal consequences. On the opposite, amoxicillin has a wide range of drug interaction medicaments such as disulfiram, anticoagulants, heparin and is safe for use by people over 12 years. The primary advantage of amoxicillin embraces its structural form. Thus, while penicillin is synthetic, amoxicillin is semi-synthetic, which contributes to the maximal penetration of bacteria cells.
Moreover, the latter has the optimal prescription timeline, which means that it provides consistent effects in a shorter time than penicillin. Concerning ampicillin, its main use benefit refers to the fact that the drug is universal in its use since it affects both Gram-positive and Gram-negative bacteria, which means that the medication may be used against any infection. Carbenicillin, in its turn, is characterized by 50% greater effectiveness than any other antimicrobial drug, which signifies the efficiency of its use. Finally, the selected medication does not require any special storage requirements and is available for any patient community.